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t?l.3251/ FOR DUPONT USE ONLY EXPOSURE LIMITS (ASL) LIST pRBpAcg ABLS AELs are exposure limits for chemicals (or for levels of physical agents) set by the DuPont ASL Committee. arr: specify Time-Weighted Average (TWA) airborne concentrations, doses or biological limits which should not be exceeded, and applicable time periods. AELs may be set to prevent health effects from exposures for full workshifts (8- or 12-hour or to prevent effects from shorter period exposures such as irritation, narcosis, odor or nuisance (15-minute TWA). As a general guide, excursions to which short-period AELs apply should occur no more than four times per shift and a recovery period of approximately 60 minutes is required between excursions. In addition, the corresponding full shift (8- or 12-hour) art. should not be exceeded. hats are set by the DuPont ASL Committee, which includes experts in toxicology, industrial hygiene, occupational medicine, pathology, and epidemiology. AlLs are based on the best available information from industrial experience, animal studies, and controlled human studies. They are guidelines based on informed judgment, and are not fine limits between safe and dangerous concentrations. -They are not for use as relative toxicity indexes, limits for continuous uninterrupted exposure, or proof or disproof of health effects. They should be interpreted and applied by appropriately qualified personnel. Specific questions or consequences of occasional excursions above an ASL should be addressed to the Safety, Health and Environmental Affairs (SHIA) manager for your business or staff function. DuPont Engineering Standard provides guidelines for evaluation of air sampling data. An AEL is established in three steps. The first step is a request for an ASL by a business or staff function.? The second is a review of the available toxicity and human health data followed either by a recommendation for a provisional ASL or a recommendation for additional information additional testing, or more complete test'data from another company). An ASL is provisional, typically for six months.- At the end of this provisional period, the ASL is reviewed again in light of any new data, before it is declared to be a final ASL. This review, the third step, concludes the process. An ASL goes into effect once it becomes final. ASLs are updated every five years, or sooner if warranted by new data, by a special subcommittee appointed by the ASL Committee. If this update indicates new data are available that might result in a change in the ASL, the chemical is referred back to the ASL Committee for review. Note: Material Safety Data Sheets for the chemical or mixtures containing the chemical must be revised within 90 days of the provisional ASL being established. USEPA 15743 1

a FOR DUPONT USE ONLY COMMUNITY A Community Exposure Guideline (CEO) 1; an .xpogur. quid.11n. (r . established by Haskell Laboratory. The assume. a 24-hour lifetime exposure by all, including the most sensitive individuals, in an exposed community population. Exposure above the C86 will not necessarily result in any adverse effects. Where data indicates that the C86 may be approached or exceeded, Haskell, the appropriate business, and Legal will evaluate what action, if any, should be taken. It is the Company's intent to maintain exposure below the C86. CEGs may be recommended for air or water or for both. he with AELs, CEGs are based on the best available information from industrial experience, animal toxicity studies, controlled human exposure studies, and epidemiological findings. However, because of the variability of sensitivities of members of the community the infirm, the old, the young, pregnant females, etc.), versus the healthy worker involved with an AEL, a larger uncertainty factor needs to be used in extrapolating these data to a C86. EMERGENCY EXPOSURE LIMITS (EELS) EELs are set for emergency situations, such as a pill or accidental release of a chemical. They specify brief durations and concentrations from which escape is feasible without any - escape-impairing or irreversible effects on health. EBLs are only applicable to emergency situations where occurrence is expected to be rare in the lifetime of an individual. OTHER SOURCES OF EXPOSURE LIMITS ABLs supplement any mandatory regulatory limits developed by national or local governmental agencies. The more stringent limit, either that developed by DuPont or by the regulatory agency, shall apply. The American Conference of Governmental Industrial hygienists (ACGIH) annually publishes a booklet containing Threshold Limit Values (TLVs) for many chemical substances and physical agents. Also,.the American Industrial Hygiene Association (AIRA) publishes Workplace Environmental Exposure Limits (waste) for I some chemicals not found in the TLV booklet. ACGIH TLVs and WEELs should be used as guidelines~for workplace exposures if no. other more apprOpriate limit exists. If a business or staff function has some concern about the validity of a TLV or HEEL, then the ASL Committee should be asked to establish an ABL. .5. other compilations of limits American Society of Testing and Materials and American National Standards Institute (ANSI) should be used after consultation with your SHEA Manager and with Haskell Laboratory. ?00000an I -2-

ago P132173 FOR DUPONT USE ONLY HAZARD DETERKINATION In DuPont, hazard determination is defined in a corporate policy (1) quoted below: when toxicologic and/or epidemiologic data indicate that a chemical might present a carcinogenic, reproductive, developmental, or germ-cell mutagenic hazard, any business or staff function which proposes to initiate the hasard determination procedure shall inform other interested businessos_and staff functions before issuing a formal request for such determination. Following receipt of the request, the Director of Haskell Laboratory and Corporate Medical shall evaluate the data, and after review by the Vice President of Safety, Health and Environment shall discuss their evaluation with the involved businesses and/or staff functions. This discussion should cover the extent of knowledge about the hazard associated with the chemical and should also give an indication about the potency of the chemical. The Director of Haskell Laboratory and Corporate Medical will confirm the results of the discussion by letter to the appropriate SESA manager(s) or their representative. Carcinogens. developmental and reproductive toxins, and germ-cell mutagens are defined as follows: Carcinogen - A substance or agent with the potential to 3 pro uce or incite cancer. For The Carcinogen Classification System, a weight of evidence analysis is used with all the i following factors considered in the evaluation (NOTE: These factors are net listed with any rank or priority). The categories included in the carcinogen Classification System are found on the next page. Amount of chemical (dose) required to produce the effect Route of exposure relative to potential human experience Type of tumor(s), site of tumors, and whether the tumors are benign or malignant a Number of animal species affected Tumor incidence a Time to tumor formation a Genotosicity data 0 Mechanistic data Pharacokinetics and metabolism. Structure Activity Relationship Epidemiologic studies "Guidelines: Control of carcinogenic, Reproductivo, Developmental. and Germ-Cell Mutagenic Risks Posed by Chemicals nade or Used within DuPont". BLC Corporate Policy and Guidelines. IIC (September 1991). 3700000817? -3- USEPA15745

P1.3217.4 . I son DUPONT US: ONLY . C-H (C) (NC) mcmocsu cusszucmos srs-rrn snows sum cancmocsu - . Substances which are known to be carcinogenic in hunans. There is sufficient evidence. based on epideeiology data, to establish a causal association between exposure.to the substance and the developaent of cancer. PROBABLE HUMAN CARCINOGEN (POTENT ANIHAL CARCINOGEN) b7?? There is sufficient evidence in one or nore adequately v/ conducted studies that the substance is clearly carcinogenic in experimental aninals. There are no epideliology data available or the existing epideaiology data are conflicting or linited/insufficient to establish a causal association between human exposure and the development of cancer. POSSIBLE HUMAN CARCINOGEN (WEAK ANIHAL CARCINOGEN OR LIMITED EVIDENCE IN ANIHALS) There is soae or liaited evidence it the substance is, carcinogenic in experinental animals. There are no epidemiology data available or the existing epideaiology data are conflicting or liaited/insufficient to establish a causal association between huaan exposure and the development of cancer. NOT LIKELY TO BE A HUMAN CARCINOGEN (ANIHAL CARCINOGEN UNLIKELY TO SAVE HUMAN RELEVANCE, There is sufficient or limited evidence in experimental animal studies that the substance is carcinogenic at high dose levels (may have exceeded the HTD), by routes of administration, in tissues, or by mechanisms that are not considered relevant to potential hulan exposure. NOT CONSIDERED TO BE A CARCINOGENIC HAZARD TO BUHANS (LACK OF EVIDENCE CARCINOGENICITY) There is evidence from an adequately conducted? experimental animal study showing a lack of carcinogenicity. If-any epidemiology evidence exists, it supports the conclusion that there is no known association between exposure and and increase in cancer risk to huaans. -4- soobooarm USEPA 15746

Develo mental Toxin - An agent with the potential to interfere with the development 0! an individual while in utero or after birth. Potency is determined by the Developmental aasard Index (081) which is the ratio or the minimum dose?toxic to the mother and the minimum dose toxic to the conceptus. Substances or agents with bars of greater than are considered potent and are identitied on the ASL List by a capital letter 3 to 5 indicate a less potent substance or agent and are identitied on the AIL List by a small letter d; substances or agents with a but of less than 3 are not considered developmental toxins and are identified on the ASL List by a in parentheses, (D). Re roductive Toxin - An agent with the potential to attect adversely the reproductive process of adult males and/or' females. Potency is determined as follows: Reproductive toxicity occurred at a dose level considerably below that resulting in other signs or toxicity. These substances or agents are considered potent and are indicated on the ASL List by a capital letter R. male or :emal' will also be indicated it reproductive toxicity occurred only in one sex. Reproductive toxicity occurred at a dose level at or just below that resulting in other signs of toxicity. These substances or agents are considered less potent and are identified on the ABL List by a small letter r. hale or female will also be indicated it reproductive toxicity occurred only in one sex. If reproductive toxicity occurred, but only at a dose level considerably greater than that resulting in other signs of texicity, these substances or agents are not considered reproductive toxins and are identitied on the ASL List by an a in parentheses. (R). USEPA 15747

P1.3217.6 FOR DUPONT USE ONLY Germ-Cell Mutagen - A genotoxic agent uith the potential to . cause permanent heritable damage in germ (reproductive) cells of expesed individuals. A substance is identified as a mutagen if it is: A proven human germ?cell mutagen, I Pesitive in a mammalian in vivo germ-cell assay tor gene mutatiens er chromosome aberrations. or Pesitive in'a mammalian in vivo somatic (non-reproductive) cell assay (or gene mutations or chromosome aberrations, and, in addition. the substance is either positive in a mammalian In vIvo germ?cell assay tor DNA damage and repair, gEfTs Identified en the AIL List as a reproductive toxin. In evaluating experimental studies in mammals, the tollewing factors are considered: The experimental design and reute of administratien. The dose required to preduce genotoxicity. The magnitude e: the genotexic respense and the presence .0: a dose-response relationship. The general cencerdance e: positive findings among different germ-cell genetoxicity assays (it known). The genetic endpeint assessed (gene mutations, chremesome aberrations, DNA repair). Petent mutagens are identified on the AIL List by a capital letter whereas less potent mutagens receive a small letter m. Agents not censidered to be mutagens are identified by a capital letter a in parentheses, Potent germ-cell mutagen categorizatien is primarily applied te: Proven human germ-cell mutagens, or Experimental mammalian germ-cell mutagens with a strong evidence e2 causing genotoxic damage in humans. In general, validated germ-cell mutagens in experimental mammals receive a small letter I. Although genotoxic agents also affect somatic (non- reproductive) cells, the guidelines described here address only genetic damage to germ cells. Genotoxic effects on somatic cells are usually addressed in carcinogen hasard determinations (see page 3). .6- LMXWOHDM USEPA l5748

FOR DUPONT USE ONLY P1321720 ABL LIST mn/ - CHEMICAL ABL REMARKS STATUS 3L8 GUIDELINES tChlorinuron Ethyl 10 ng/I3 8- and 12-hour TVA. 1992 (Used in Classic? totnl dust Herbicide) 5 ugluk 8- and 12-hour TVA, (DPX-P6025) dust [90982-32-4] tChlorine 0.5 8- and 12-hour WA 91994 [7782-50-5] 1 15-Iinuto TVA n-Chloroanilino 0.5 pp: 8- :nd 12-h0ur TVA, 1988 [108-42-9] skin o-Chloroanilino 2 8- and 12-hour TVA, 1988 '[95-51-2] skin p-Chloroanilinc 0.5 ugll? 8-hour TVA, skin 1988 1988 [106-47~8] 0.3 Isl-3 12-hour TVA, skin (R 1988)* TChlorobenzeno 23 8- and 12-hour um 1986 (no 1986,)9 [108-90-7] (D 1986)* 1-Chloro-1.1-dit1uorocthunc Sec SQ. ECPC-ZZ So. 8870-31 tChloroform 2 pp. 8- and 12-hour TVA 1993 1993 [67-66-31 (D 1993)* (R 1993)* (H 1993)* 0.1 13/33 8- 9nd 12-hour TVA 1991 [2682-20?4] Iixturc with [26172-55-4] (Kathono chloroptcno 10 8- and 12-hour TVA 1988 [126-99-8l 1 1 fluoroothanc SO. Substances or agonts rovicvcd recording to 31? Guidelines and not considcrod to be a carcinogenic, dovelopnontal. roproductivo, or torn-c011 mutagonic hazard are indicatod by the appropriate lotto: vithin parenthasos. 0.3., (NC), (D), (R), or (H). June 17, 1994 -10- USEPA 15762

FOR DUPONT USE ONLY CHEMICAL Ammonia Carbon Honoxidc Chlorine Chloroprene Chlorosulfonic Acid 1,A-Dichloro- butane-2 fN,N-Dimethyl- aniline Dinothyl Sulfate Fluorobenzenq Fluorosulfonic Acid Formald?hydn Halon 2402 BCFC-31 Hexafluo:o- propylene June 17, 1994 EMERGENCY EXPOSURB LIMITS BBL 500 300 pppp. 2000 ppm-min 20 lag/II1 10 ng/IJ 120 ppm-min 400 pp- 100 pp- 30 ppm-Iinutcs 2000 1000 pp- 10 nzll? 5 Isl-3 10 pp. 500 2500?- 1000 pp- 1000 pp- 6000 ppm-sin TIER PERIOD mum 10 linutcs 500 pp. . 10-60 minutes 10 ninutns 900 10-60 minutes 1 ninuto 10 pp. 1-5 linutcs 5-60 Ilnutes 60 linutcs 2000 pp- 15 minute: 20 .3133 15-60 minutes 60 minutes 2 10 minute 600 ppn' 11-60 ninutes 60 nxnutcs 2 ppn' 1 ninutn 2000 pp: 2-60 ninutcs A 15 ninutca 10 15-60 ninutcs 60-n1nutcs 10 pp- 15 ninuto: 500 pp- 1-I1nutc 2500 2-60 linutes 2-60 ninutes 2500 pp- 60 ninutcs 1000 pp- - 55 - P1321766 90000151? USEPA [5808

?1 FOR DUPONT USE ONLY P1.3217.69 COMMUNITY EXPOSURB GUIDELINES Airborne Guidelines CHEMICAL Acetic Acid Acrylonitrile Ammonium Periluorooctanoate .Benzene 1,3-Butadiene Carbon Tetrachloride Carbonyl Sulfide Chlorine Chloroform Chloroprene Dibromomethane Dimethylacetemide 1,4-Dioxane Dodecenedioic Acid Bthanolamine Ethylene Dibromide Ethylene Dichloride FC-116 (Rexafluoroethane) Formaldehyde 1,4-Hexadiene n-Hexane RFC-23 (Tritluoromethane) RFC-125 (Pentafluoroethane) .Bydrogen Chloride Hydrogen Cyanide Hydrogen Fluoride Haleic Hethyl Chloride Methylene Chloride Nitrogen Dioxide June 17. 1994 E25 1 6015) 20 0.0003 "In, 0.05 0.1 0.1 0.2 I 0.05 0.2 0.5 1 0.4 1 0.5 mg/m? (total duet0.1 0.01 2 10 pp- 10 0.2 (60-minute TVA) in? combinetion with the Rational Ambient Air Quality Stenderd of 100 ug/m3 (0.053 ppm) - Annual arithmetic mean 59 - USEPA 1581]